A community stronger than HIV.

SUPER:	Danny is an actual SYMTUZA^® patient. Danny has been compensated by Janssen. This is not medical advice.
DANNY:	As an artist, the stage is my second home. When I’m on the stage, I’m the queen of the world. My name is Danny, I’m 33 years old and I live in Boston. I was born and raised in Medellin, Colombia. The drag queens and the transgender community there is very stigmatized and I grew up thinking the same bad stereotypes. When I come to the United States, I was working with this group and they did this competition and they asked me to dress up to do a performance for the Miss Colombia. And I won, I won Miss Colombia and that just give me life. That is how Dayanna was born. When I was diagnosed with HIV, I was so scared. I was scared about how my family would react. But I received a lot of love. And that was beautiful. It’s normal to struggle, it’s normal to feel down. So that’s why it’s important to have emotional support. The diagnosis was an opportunity to take care of myself, to move forward in life. Performing as Dayanna, it helped me to move forward with my visibility as a person living with HIV. She makes me feel powerful. Dayanna is freedom. Danny, thank you for giving me life. Pretty sure that we both can just get far far, and just achieve whatever we want. I has been undetectable and I’m still undetectable
SUPER:	Undetectable is defined as <50 copies/mL.
DANNY:	Before, I was on some other treatments. The biggest reason to change was the number of pills that I was taking a day. SYMTUZA^® is convenient for me because it’s one pill.
SUPER:	Take SYMTUZA^® (darunavir/cobicistat/emtricitabine/tenofovir alafenamide tablets 800mg/150mg/200mg/10mg) one time a day with food. Do not miss a dose of SYMTUZA^®.
DANNY:	One time a day is perfect.
AVO/SUPER:	WHAT IS SYMTUZA^®? SYMTUZA^® (darunavir/cobicistat/emtricitabine/tenofovir alafenamide tablets) is a prescription medicine that is used without other antiretroviral medicines to treat Human Immunodeﬁciency Virus-1 (HIV-1) infection in adults and in children who weigh at least 88 pounds (40 kg) who: have not received anti-HIV-1 medicines in the past, or when their healthcare provider determines that they meet certain requirements. HIV-1 is the virus that causes Acquired Immune Deﬁciency Syndrome (AIDS). It is not known if SYMTUZA^® is safe and eﬀective in children weighing less than 88 pounds (40 kg).

IMPORTANT SAFETY INFORMATION
WHAT IS THE MOST IMPORTANT INFORMATION I SHOULD KNOW ABOUT SYMTUZA^®?

SYMTUZA^® can cause serious side effects including:

Worsening of hepatitis B virus infection. Your healthcare provider will test you for hepatitis B virus (HBV) before starting treatment with SYMTUZA^®. If you have HBV infection and take SYMTUZA^®, your HBV may get worse (flare-up) if you stop taking SYMTUZA^®.
- Do not stop taking SYMTUZA^® without first talking to your healthcare provider.
- Do not run out of SYMTUZA^®. Refill your prescription or talk to your healthcare provider before your SYMTUZA^® is all gone.
- If you stop taking SYMTUZA^®, your healthcare provider will need to check your health often and do blood tests regularly for several months to check your HBV infection or give you a medicine to treat your HBV infection. Tell your healthcare provider about any new or unusual symptoms you may have after you stop taking SYMTUZA^®.
Change in liver enzymes. People with a history of hepatitis B or C virus infection or who have certain liver enzyme changes may have an increased risk of developing new or worsening liver problems during treatment with SYMTUZA^®. Liver problems can also happen during treatment with SYMTUZA^® in people without a history of liver disease. Your healthcare provider may need to do tests to check your liver enzymes before and during treatment with SYMTUZA^®.
Severe liver problems. In rare cases, severe liver problems can happen that can lead to death. Tell your healthcare provider right away if you get these symptoms:
- Skin or the white part of your eyes turn yellow
- Dark "tea-colored" urine
- Light-colored stools
- Loss of appetite for several days or longer
- Nausea
- Vomiting
- Stomach area pain

SYMTUZA^® may cause severe or life-threatening skin reactions or rashes which may sometimes require treatment in a hospital. Call your healthcare provider right away if you develop a rash. Stop taking SYMTUZA^® and call your healthcare provider right away if you develop any skin changes with symptoms below:

Fever
Tiredness
Muscle or joint pain
Blisters or skin lesions
Mouth sores or ulcers
Red or inflamed eyes, like "pink eye" (conjunctivitis)

Who should not take SYMTUZA^®?

Do not take SYMTUZA^® with any of the following medicines: alfuzosin, carbamazepine, colchicine (if you have liver or kidney problems), dronedarone, elbasvir and grazoprevir, ergot-containing medicines (such as: dihydroergotamine, ergotamine tartrate, methylergonovine), ivabradine, lomitapide, lovastatin or a product that contains lovastatin, lurasidone, midazolam (when taken by mouth), naloxegol, phenobarbital, phenytoin, pimozide, ranolazine, rifampin, St. John's wort (Hypericum perforatum) or a product that contains St. John's wort, sildenafil when used for pulmonary arterial hypertension (PAH), simvastatin or a product that contains simvastatin, or triazolam.
Serious problems can happen if you take any of these medicines with SYMTUZA^®. This is not a complete list of medicines. Therefore, tell your healthcare provider about all medicines you take.

Before taking SYMTUZA^®, tell your healthcare provider about all of your medical conditions, including if you:

have liver problems (including hepatitis B or hepatitis C), have kidney problems, are allergic to sulfa (sulfonamide), have diabetes, have hemophilia, or have any other medical condition.
are pregnant (if you become pregnant while taking SYMTUZA^®), or plan to become pregnant. It is unknown if SYMTUZA^® will harm your unborn baby.
- SYMTUZA^® should not be used during pregnancy.
are breastfeeding or plan to breastfeed. Do not breastfeed if you take SYMTUZA^®.

Tell your healthcare provider about all the medicines you take, including prescription and over-the-counter medicines, topical creams, vitamins, and herbal supplements. Some medicines interact with SYMTUZA^®. Keep a list of your medicines to show your healthcare provider and pharmacist. Do not start taking a new medicine without telling your healthcare provider.

HOW SHOULD I TAKE SYMTUZA^®?

Take SYMTUZA^® 1 time a day with food.

WHAT ARE THE POSSIBLE SIDE EFFECTS OF SYMTUZA^®?

SYMTUZA^® may cause serious side effects including:

See "What is the most important information I should know about SYMTUZA^®?"
Immune system changes can happen in people who start HIV medications.
New or worse kidney problems, including kidney failure.
- Your healthcare provider should do blood and urine tests to check your kidneys before you start and while you are taking SYMTUZA^®.
Too much lactic acid in your blood (lactic acidosis).
- Too much lactic acid is a serious but rare medical emergency that can lead to death. Tell your healthcare provider right away if you get these symptoms: weakness or being more tired than usual, unusual muscle pain, being short of breath or fast breathing, stomach pain with nausea and vomiting, cold or blue hands and feet, feel dizzy or lightheaded, or a fast or abnormal heartbeat.
Diabetes and high blood sugar (hyperglycemia). Some people who take protease inhibitors including SYMTUZA^® can get high blood sugar, develop diabetes, or your diabetes can get worse. Tell your healthcare provider if you notice an increase in thirst or if you start urinating more often while taking SYMTUZA^®.
Changes in body fat can happen in people taking HIV-1 medications.
Increased bleeding can occur in people with hemophilia who are taking SYMTUZA^®.

The most common side effects of SYMTUZA^® are: diarrhea, rash, nausea, fatigue, headache, stomach problems, and gas.

These are not all of the possible side effects of SYMTUZA^®.

Call your doctor for medical advice about side effects. You are encouraged to report negative side effects of prescription drugs to the FDA. Visit http://www.fda.gov/medwatch or call 1-800-FDA-1088. You may also report side effects to Janssen Products, LP at 1-800-JANSSEN (1-800-526-7736).

Please see full Product Information, including Boxed Warning at SYMTUZA.com.

SUPER:

cp-62077v7

SUPER:	Nathan is an actual SYMTUZA^® patient. Nathan has been compensated by Janssen. This is not medical advice.
NATHAN:	Clothing is so important. It represents who I am. I look for unique pieces, I want something different, maybe not everybody is wearing. And if they are, how can I rock it different? My name is Nathan. I reside in Houston, Texas, and I'm 44 years old. Fashion is a way for me to explore, be creative, be daring sometimes, and you know, be free. I have a love for fashion, clothes, and shoes. That came from my mother. I remember as a child, my mom just dressing us up, going shopping and getting excited about getting something new to wear. After my HIV diagnosis, I did share with my mom and my sister, and that was probably the scariest thing. They reaffirmed that they loved me, and they didn't judge me. That was very beautiful and powerful. I do have a chosen family. Chosen family is someone that's not related to you by blood, that you have a special connection with. It is people that have come into your life, you believe in them, they believe in you. They're there to support each other and give love. I have several what we call gay kids or kids that are in the community. And then it’s a host of good friends that are part of that chosen family circle. On this journey, I appreciate the support of the community and my chosen family. I didn't have to take this journey by myself. Twenty years ago, I did not think I would be here. I honestly thought I would live to be 30, and so here I am, 44... thriving. The medicine is doing what it's supposed to do, keeping my numbers where they are, and that's what's most important. I took an active role by really doing some research, checking out what's out there, what's available, what the side effects are. My experience with SYMTUZA^® has been good. I just take one pill a day.
SUPER:	Take SYMTUZA^® (darunavir/cobicistat/emtricitabine/tenofovir alafenamide tablets 800mg/150mg/200mg/10mg) one time a day with food. Do not miss a dose of SYMTUZA^®.
NATHAN:	I love it.
AVO/SUPER:	WHAT IS SYMTUZA^®? SYMTUZA^® (darunavir/cobicistat/emtricitabine/tenofovir alafenamide tablets) is a prescription medicine that is used without other antiretroviral medicines to treat Human Immunodeﬁciency Virus-1 (HIV-1) infection in adults and in children who weigh at least 88 pounds (40 kg) who: have not received anti-HIV-1 medicines in the past, or when their healthcare provider determines that they meet certain requirements. HIV-1 is the virus that causes Acquired Immune Deﬁciency Syndrome (AIDS). It is not known if SYMTUZA^® is safe and eﬀective in children weighing less than 88 pounds (40 kg).

- Nausea
- Vomiting
- Stomach area pain

Fever
Tiredness

SUPER:

cp-62077v7

SUPER:	Helen is an actual SYMTUZA^® patient. Helen has been compensated by Janssen. This is not medical advice.
HELEN:	I cried because of the trauma that I had gone through. I said, I'm not going to let another woman go through what I went through. That’s when I started advocating. My name is Helen. I live in Dallas, Texas, and I'm 56 years old. When I got diagnosed, I was pregnant with my son. The doctor, he said that um, if I choose to keep the pregnancy, I might die or the child might die. But then I had a child at the house, you know, my daughter. If I die, what’s going to happen to her? All I knew is that I had hope. They wanted me to, um, to get rid of the pregnancy. And at that time, I had just made up my mind that, no, I'm not going to do that. When I found out that my child was HIV negative, I was so happy. I went 9 months not knowing what's going to happen not knowing that I'm not alone. And I made up my mind that from that time, I'm going to be available for another woman. That's how my advocacy started. My current responsibility is to listen to the voices of the women, especially Black women in the community and connect them with the services they need. HIV is not a death sentence. It is going to be OK. Because there's always somebody out there to help you. My advocacy work has helped me to move forward because every time I make it happen for another person, it makes me feel better. I'm a busy person. One pill a day is the biggest reason why I switched, as a single mom, working and trying to do everything else, it's not easy to stop, take medication, stop, take medications…
SUPER:	Take SYMTUZA^® (darunavir/cobicistat/emtricitabine/tenofovir alafenamide tablets 800mg/150mg/200mg/10mg) one time a day with food. Do not miss a dose of SYMTUZA^®.
HELEN:	SYMTUZA^® ﬁts with my lifestyle perfect.
AVO/SUPER:	WHAT IS SYMTUZA^®? SYMTUZA^® (darunavir/cobicistat/emtricitabine/tenofovir alafenamide tablets) is a prescription medicine that is used without other antiretroviral medicines to treat Human Immunodeﬁciency Virus-1 (HIV-1) infection in adults and in children who weigh at least 88 pounds (40 kg) who: have not received anti-HIV-1 medicines in the past, or when their healthcare provider determines that they meet certain requirements. HIV-1 is the virus that causes Acquired Immune Deﬁciency Syndrome (AIDS). It is not known if SYMTUZA^® is safe and eﬀective in children weighing less than 88 pounds (40 kg).

- Nausea
- Vomiting
- Stomach area pain

Fever
Tiredness

SUPER:

cp-62077v7

SUPER:	Brandon is an actual SYMTUZA^® patient. Brandon has been compensated by Janssen. This is not medical advice.
BRANDON:	So what we cookin’? We cookin’ baked chicken and rice and steamed veg tonight. That’s for dinner. And then we’re gonna sit it in the oven so that it can bake where the meat will fall off the bone. Right, love? Okay. My name is Brandon. I’m 31 years old. Cooking is my thing. When I’m cooking soul food for my household, it always brings back memories of me growing up, how I used to be in the kitchen with my grandmother or my mom when they’re cooking their soul food. Everybody would bring in different dishes to my mother’s house. We’ll just get around the table as a family and we’ll just eat. When you have something from the South and it’s made soul food way, you’re gonna always remember it. When I found out that I was diagnosed with HIV, it’s like my world had shattered. The first person I called was my mother ‘cause that’s my mom and I had to let her know. Cooking makes me not think about the things that are going on in my life. For me, it eases my mind. When I’m down, I’ll come in the kitchen to cook. Cooking with my husband every night, and preparing a dish that we always love… it’s amazing. We put our heart, we put our all into, what we’re going to sit down at the table to eat. It’s causing me to just not want to give up on life. We want to start a Caribbean soul food restaurant. Life doesn’t stop. I’m still healthy, I’m still here, and I’m just gonna keep living. I choose to continue to take my medication, every day, on time. Just one pill a day, no shots. That’s it.
SUPER:	Take SYMTUZA^® (darunavir/cobicistat/emtricitabine/tenofovir alafenamide tablets 800mg/150mg/200mg/10mg) one time a day with food. Do not miss a dose of SYMTUZA^®.
BRANDON:	I have heard that gaining weight could be a side eﬀect with certain medication. Me, I haven’t gained any weight. I ﬁrst heard about SYMTUZA^® through my doctor.
SUPER:	Individual results may vary. He recommended me to start the very next day, so that they can get my viral load under control. From that day I haven’t deviated from SYMTUZA^®.
AVO/SUPER:	WHAT IS SYMTUZA^®? SYMTUZA^® (darunavir/cobicistat/emtricitabine/tenofovir alafenamide tablets) is a prescription medicine that is used without other antiretroviral medicines to treat Human Immunodeﬁciency Virus-1 (HIV-1) infection in adults and in children who weigh at least 88 pounds (40 kg) who: have not received anti-HIV-1 medicines in the past, or when their healthcare provider determines that they meet certain requirements. HIV-1 is the virus that causes Acquired Immune Deﬁciency Syndrome (AIDS). It is not known if SYMTUZA^® is safe and eﬀective in children weighing less than 88 pounds (40 kg).